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Racine stages : ウィキペディア英語版
Racine stages
Racine stages are a categorization of epileptic seizures proposed by Ronald J. Racine in 1972. Prior to Racine's research in epilepsy, a quantifiable means to describe seizure intensities and their causes was not readily available. Racine's work allowed for epilepsy to be understood on a level previously thought impossible.
== Introduction==
In the brain, electrical signals are spread by the firing of neurons which lead to a desired outcome in the body. This can be caused by a release of a neurotransmitter or the voluntary contractions of a muscle. An action potential must be met in order for the electrical signal to be created. In epileptic patients, electrical signals reach a threshold, causing a spread of firing neurons in the brain. This causes multiple signals to spread through the nervous system resulting in a seizure. Once a seizure has occurred, damage can be seen in the area that the action potential came from.〔Brodie, MJ; Elder, AT, Kwan, P (2009 Nov). "Epilepsy in later life". Lancet neurology 8 (11): 1019–30〕 For example, if the initial action potential came from the hippocampus, damage can be seen in the surrounding neurons.
While an EEG is able to determine the presence of a seizure and the intensity of the action potentials, the overall result on the body is hard to determine. In 1972, Ronald J. Racine developed a method to split the severity of seizures into stages: mouth and facial movement, head nodding, forelimb clonus, rearing with forelimb clonus, and rearing and falling with forelimb clonus. Racine stages can be used to determine at which stages the patient is experiencing a seizure and at what level of stimulus the patient is able to reach a certain stage. Over time, mapping of the stimulus level and the resulting seizure intensity can show damage to the stimulated area. Mappings for patients can be made by sending electrical signals at different strengths to measure the body's reaction.〔 Once the epileptic patient experiences a seizure, the patient becomes more susceptible to having further seizures. Racine stages were developed using an animal model to outline the five stages.〔 Once developed, the Racine stages served as a quantitative way to categorize the intensity of a seizure that an epileptic patient experiences.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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